Based on available evidence, it is suggested that reproductive-aged women should consume </=300 mg caffeine per day (equivalent to 4.6 mg kg(-1) bw day(-1) for a 65-kg person) while children should consume </=2.5 mg kg(-1) bw day(-1). For those who have frequent headaches, avoidance of all caffeine is ideal, and at least until improvement in headache frequency is seen. The data also show that reproductive-aged women and children are 'at risk' subgroups who may require specific advice on moderating their caffeine intake. For people who experience migraine, caffeine taken three or more days per week, for whatever reason, may lead to dependency and increased migraine frequency. Based on the data reviewed, it is concluded that for the healthy adult population, moderate daily caffeine intake at a dose level up to 400 mg day(-1) (equivalent to 6 mg kg(-1) body weight day(-1) in a 65-kg person) is not associated with adverse effects such as general toxicity, cardiovascular effects, effects on bone status and calcium balance (with consumption of adequate calcium), changes in adult behaviour, increased incidence of cancer and effects on male fertility. The possibility that caffeine ingestion adversely affects human health was investigated based on reviews of (primarily) published human studies obtained through a comprehensive literature search. Because of its wide consumption at different levels by most segments of the population, the public and the scientific community have expressed interest in the potential for caffeine to produce adverse effects on human health. To learn more about the amount of caffeine in different energy drinks, shots, coffee or tea, check out other products we've researched. It is found in common beverages (coffee, tea, soft drinks), in products containing cocoa or chocolate, and in medications. Ultimately, the caffeine in Redline Xtreme Energy Drink is safe all that matters is how much of it you drink. Caffeine is probably the most frequently ingested pharmacologically active substance in the world.
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